Solfametopirazina [Dcit]
Brand names,
Solfametopirazina [Dcit]
Analogs
Solfametopirazina [Dcit]
Brand Names Mixture
Solfametopirazina [Dcit]
Chemical_Formula
C11H12N4O3S
Solfametopirazina [Dcit]
RX_link
No information avaliable
Solfametopirazina [Dcit]
fda sheet
Solfametopirazina [Dcit]
msds (material safety sheet)
Solfametopirazina [Dcit]
Synthesis Reference
No information avaliable
Solfametopirazina [Dcit]
Molecular Weight
280.304 g/mol
Solfametopirazina [Dcit]
Melting Point
169.5 oC
Solfametopirazina [Dcit]
H2O Solubility
4030 mg/L
Solfametopirazina [Dcit]
State
Solid
Solfametopirazina [Dcit]
LogP
1.441
Solfametopirazina [Dcit]
Dosage Forms
Tablet
Solfametopirazina [Dcit]
Indication
For the treatment of urinary tract infection and chronic bronchitis.
Solfametopirazina [Dcit]
Pharmacology
Sulfametopyrazine is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus.
Solfametopirazina [Dcit]
Absorption
No information avaliable
Solfametopirazina [Dcit]
side effects and Toxicity
No information avaliable
Solfametopirazina [Dcit]
Patient Information
Solfametopirazina [Dcit]
Organisms Affected
Gram negative, positive bacteria and plasmodium